Genome Analysis for Hereditary Cardiovascular Diseases

Purpose：

The identification of causative genes for various hereditary cardiovascular diseases has been conducted in the past. The identification of causative genes may lead to the elucidation of new pathogenesis and to the development of diagnosis and treatment based on it. The purpose of this study is as follows;

  1. To conduct genetic analysis of patients and their families affected by hereditary cardiovascular diseases and to identify the related genes.
  2. To feed back the results and disease information to the patients when the diagnosis is confirmed.
  3. To create new knowledge that will lead to the treatment of rare and intractable cardiovascular diseases.

Research Period

Dec. 1st, 2010. – May. 31st, 2022. (ongoing)

Subject

Patients with suspected hereditary cardiovascular diseases and their families

Number of registered cases

> 1800 cases (at April. 30th, 2021)

Genome Database

GRAND-STAR (Genome Registry AND STratification of cARdiovascular disease) database is an integrated database of whole exome sequencing results and clinical information of Japanese patients with cardiovascular diseases and their family members at Osaka University Hospital. The database is shared with the research institutions that deposited the genomic data. Part of the anonymized genomic data of patients with cardiomyopathy (n = 500) has been deposited in the Human Genetic Variation Database (HGVD).

Contact information

Yoshihiro Asano, MD.PhD.
Associate Professor,
Department of Cardiovascular Medicine
Osaka University Graduate School of Medicine
2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
TEL +81-6-6879-3472
FAX +81-6-6879-3473

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